Kazutaka Higaki: search on Z-Library

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1

Establishment of new preparation method for solid dispersion formulation of tacrolimus

Kazunari Yamashita, Toshiomi Nakate, Kazuto Okimoto, Atsuo Ohike, Yuji Tokunaga, Rinta Ibuki, Kazutaka Higaki, Toshikiro Kimura

Journal:

International Journal of Pharmaceutics

Year:

2003

Language:

english

File:

PDF, 430 KB

english, 2003

2

Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo ( Gnetum gnemon L.) Seed Extract Powder

Tani, Hiroko, Hikami, Susumu, Iizuna, Sanae, Yoshimatsu, Maiko, Asama, Takashi, Ota, Hidetaka, Kimura, Yuka, Tatefuji, Tomoki, Hashimoto, Ken, Higaki, Kazutaka

Journal:

Journal of Agricultural and Food Chemistry

Year:

2014

Language:

english

File:

PDF, 1000 KB

english, 2014

3

Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer

Kazutaka Higaki, Masahide Asai, Takayuki Suyama, Kazuki Nakayama, Ken-ichi Ogawara, Toshikiro Kimura

Journal:

International Journal of Pharmaceutics

Year:

2002

Language:

english

File:

PDF, 500 KB

english, 2002

4

Evaluation of factors affecting gastrointestinal absorption of a novel anticoagulant FX-93 for development of oral formulation

Shigeo Takemura, Hiromu Kondo, Kenichi Suzumura, Ken-Ichi Ogawara, Shunsuke Watanabe, Kazuhiro Sako, Kazutaka Higaki

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 335 KB

english, 2012

5

Analysis and Prediction of Absorption Behavior for Theophylline Orally Administered as Powders Based on Gastrointestinal-transit-Absorption (Gita) Model

Kadono, Keitaro, Yokoe, Jun-ichi, Ogawara, Ken-ichi, Higaki, Kazutaka, Kimura, Toshikiro

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2002

Language:

english

File:

PDF, 279 KB

english, 2002

6

Prediction of the Plasma Concentration Profiles of Orally Administered Drugs in Rats on the Basis of Gastrointestinal Transit Kinetics and Absorbability

TAIJI SAWAMOTO, SHUNJI HARUTA, YUJI KUROSAKI, KAZUTAKA HIGAKI, TOSHIKIRO KIMURA

Journal:

Journal of Pharmacy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 672 KB

english, 1997

7

Nanoparticle-Based Photodynamic Therapy: Current Status and Future Application to Improve Outcomes of Cancer Treatment

Ogawara, Ken-ichi, Higaki, Kazutaka

Year:

2017

Language:

english

File:

PDF, 1.39 MB

english, 2017

8

Time-Dependent Oral Absorption Models

Kazutaka Higaki, Shinji Yamashita, Gordon L. Amidon

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

2001

Language:

english

File:

PDF, 257 KB

english, 2001

9

In vitro–in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol

Jun-ichi Jinno, Naoki Kamada, Masateru Miyake, Keigo Yamada, Tadashi Mukai, Masaaki Odomi, Hajime Toguchi, Gary G. Liversidge, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Controlled Release

Year:

2008

Language:

english

File:

PDF, 1009 KB

english, 2008

10

Evaluation of absorption kinetics of orally administered theophylline in rats based on gastrointestinal transit monitoring by gamma scintigraphy

Shunji Haruta, Keiichi Kawai, Seishi Jinnouchi, Ken-ichi Ogawara, Kazutaka Higaki, Shozo Tamura, Kazuhiko Arimori, Toshikiro Kimura

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 282 KB

english, 2001

11

Gastrointestinal Transit and Drug Absorption

Kimura, Toshikiro, Higaki, Kazutaka

Journal:

Biological & Pharmaceutical Bulletin

Year:

2002

Language:

english

File:

PDF, 216 KB

english, 2002

12

Carrier-mediated transport systems for glucose in mucosal cells of the human oral cavity

Yujiro Oyama, Hitoshi Yamano, Akiko Ohkuma, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 110 KB

english, 1999

13

Sex differences in pharmacokinetics of cilostazol in rats

Kamada, Naoki, Yamada, Keigo, Odomi, Masaaki, Mukai, Tadashi, Nishibayashi, Toru, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka

Journal:

Year:

2011

Language:

english

File:

PDF, 916 KB

english, 2011

14

Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation

Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, Satoshi Ueda, Yuji Tokunaga, Rinta Ibuki, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 144 KB

english, 2006

15

Important role of serum proteins associated on the surface of particles in their hepatic disposition

Kentaro Furumoto, Ken-ichi Ogawara, Susumu Nagayama, Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Controlled Release

Year:

2002

Language:

english

File:

PDF, 252 KB

english, 2002

16

Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine

Masateru Miyake, Naoki Kamada, Yoshikazu Oka, Tadashi Mukai, Takanori Minami, Hajime Toguchi, Masaaki Odomi, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Controlled Release

Year:

2004

Language:

english

File:

PDF, 217 KB

english, 2004

17

SPIE Proceedings [SPIE Photomask and NGL Mask Technology XV - Yokohama, Japan (Wednesday 16 April 2008)] Photomask and Next-Generation Lithography Mask Technology XV - Impact of patterning strategy on mask fabrication beyond 32nm

Mimotogi, Shoji, Horiuchi, Toshiyuki, Higaki, Tomotaka, Kanai, Hideki, Tanaka, Satoshi, Satake, Masaki, Kitamura, Yosuke, Kodera, Katsuyoshi, Ishigo, Kazutaka, Kono, Takuya, Asano, Masafumi, Takahata,

Year:

2008

Language:

english

File:

PDF, 338 KB

english, 2008

18

Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium

Yoko Endo, Kiyonori Hanada, Masateru Miyake, Ken-Ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 321 KB

english, 2002

19

A novel approach to overcome multidrug resistance: Utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors

Yoshizawa, Yuta, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 819 KB

english, 2014

20

Development of Safe and Potent Oil-in-Water Emulsion of Paclitaxel to Treat Peritoneal Dissemination

Ogawara, Ken-ichi, Fukuoka, Yoshiko, Yoshizawa, Yuta, Kimura, Toshikiro, Higaki, Kazutaka

Journal:

Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 2.66 MB

english, 2017

21

Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer

Chie Takayama, Fuyuki Mukaizawa, Takuya Fujita, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 333 KB

english, 2009

22

Animal models for predicting potency of oral sustained-release adhesive microspheres in humans

Naoki Nagahara, Yohko Akiyama, Kazutaka Higaki, Toshikiro Kimura

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 224 KB

english, 2007

23

Interaction of polystyrene microspheres with liver cells: roles of membrane receptors and serum proteins

Ken-ichi Ogawara, Minoru Yoshida, Yoshinobu Takakura, Mitsuru Hashida, Kazutaka Higaki, Toshikiro Kimura

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1999

Language:

english

File:

PDF, 294 KB

english, 1999

24

Uptake by Hepatocytes and Biliary Excretion of Intravenously Administered Polystyrene Microspheres in Rats

Ogawara, Ken-Ichi, Yoshida, Minoru, Furumoto, Kentaro, Takakura, Yoshinobu, Hashida, Mitsuru, Higaki, Kazutaka, Kimura, Toshikiro

Journal:

Journal of Drug Targeting

Year:

1999

Language:

english

File:

PDF, 883 KB

english, 1999

25

Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method

Tsunashima, Daisuke, Yamashita, Kazunari, Ogawara, Ken-ichi, Sako, Kazuhiro, Higaki, Kazutaka

Journal:

Journal of Pharmacy and Pharmacology

Year:

2016

Language:

english

File:

PDF, 359 KB

english, 2016

26

Enhancement of membrane permeability to a poorly absorbed drug by medium-chain glycerides: Effect of medium-chain glycerides on the release of phenol red from egg phosphatidylcholine liposomes.

HIGAKI, KAZUTAKA, TAKECHI, NOBUYUKI, HASHIDA, MITSURU, SEZAKI, HITOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1988

File:

PDF, 519 KB

1988

27

Formulation and Evaluation of Paclitaxel-Loaded Polymeric Nanoparticles Composed of Polyethylene Glycol and Polylactic Acid Block Copolymer

Araki, Tomoya, Kono, Yusuke, Ogawara, Ken-ichi, Watanabe, Takaichi, Ono, Tsutomu, Kimura, Toshikiro, Higaki, Kazutaka

Journal:

Biological & Pharmaceutical Bulletin

Year:

2012

Language:

english

File:

PDF, 722 KB

english, 2012

28

Estimation of Intradermal Disposition Kinetics of Drugs: I. Analysis by Compartment Model with Contralateral Tissues

Kazuki Nakayama, Hisae Matsuura, Masahide Asai, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 988 KB

1999

29

Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: Improved transdermal absorption and evaluation of efficacy and safety

Naruse, Mamoru, Ogawara, Ken-ichi, Kimura, Toshikiro, Konishi, Ryoji, Higaki, Kazutaka

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 1006 KB

english, 2014

30

Determinants for In Vivo Antitumor Effect of Angiogenesis Inhibitor SU5416 Formulated in PEGylated Emulsion

Ogawara, Ken-Ichi, Abe, Shigeki, Un, Keita, Yoshizawa, Yuta, Kimura, Toshikiro, Higaki, Kazutaka

Journal:

Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

31

Organic-Inorganic Hybrid Thin Film Fabricated by Layer-by-Layer Assembly of Phosphorylated Cellulose Nanocrystal and Imogolite Nanotubes

Li, Linlin, Ma, Wei, Higaki, Yuji, Kamitani, Kazutaka, Takahara, Atsushi

Journal:

Year:

2018

Language:

english

File:

PDF, 980 KB

english, 2018

32

Appearance of Double Peaks in Plasma Concentration–time Profile after Oral Administration Depends on Gastric Emptying Profile and Weight Function

Yukiko Metsugi, Yoshihiro Miyaji, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 454 KB

english, 2008

33

Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: Utilization of a more suitable medium for in-vitro dissolution study

Yoshitsugu Fujioka, Keitaro Kadono, Yasuko Fujie, Yukiko Metsugi, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Journal of Controlled Release

Year:

2007

Language:

english

File:

PDF, 461 KB

english, 2007

34

Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides: Studies on the Membrane Permeability and Microviscosity

Kazutaka Higaki, Muneyoshi Kato, Mitsuru Hashida, Hitoshi Sezaki

Journal:

Pharmaceutical Research

Year:

1988

File:

PDF, 633 KB

1988

35

Effects of temperature, growth phase andluxO-disruption on regulation systems of toxin production inVibrio vulnificusstrain L-180, a human clinical isolate

Elgaml, Abdelaziz, Higaki, Kazutaka, Miyoshi, Shin-ichi

Journal:

World Journal of Microbiology and Biotechnology

Year:

2014

Language:

english

File:

PDF, 547 KB

english, 2014

36

In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins

Shehata, Tamer, Kimura, Toshikiro, Higaki, Kazutaka, Ogawara, Ken-ichi

Journal:

International Journal of Pharmaceutics

Year:

2016

Language:

english

File:

PDF, 533 KB

english, 2016

37

Safe Improvement of Drug Absorption by Combinatorial Use of Sodium Laurate with Amino Acids: Cytoprotection by Amino Acids and Its Mechanisms

HIGAKI, Kazutaka

Journal:

YAKUGAKU ZASSHI

Year:

2007

Language:

english

File:

PDF, 567 KB

english, 2007

38

Development of Transdermal Therapeutic Formulation of CNS5161, a Novel N-Methyl-D-aspartate Receptor Antagonist, by Utilizing Pressure-Sensitive Adhesives I

Naruse, Mamoru, Ogawara, Ken-ichi, Kimura, Toshikiro, Konishi, Ryoji, Higaki, Kazutaka

Journal:

Biological & Pharmaceutical Bulletin

Year:

2012

Language:

english

File:

PDF, 671 KB

english, 2012

39

Casein Enhances Stability of Peptides in Intestinal Lumen: Role of Digested Products of Casein

Seiji Ohtani, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura

Journal:

Pharmaceutical Research

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

40

Improved design decreases wear in total knee arthroplasty with varus malalignment

Nishikawa, Kazutaka, Okazaki, Ken, Matsuda, Shuichi, Tashiro, Yasutaka, Kawahara, Shinya, Nakahara, Hiroyuki, Okamoto, Shigetoshi, Shimoto, Takeshi, Higaki, Hidehiko, Iwamoto, Yukihide

Journal:

Knee Surgery, Sports Traumatology, Arthroscopy

Year:

2014

Language:

english

File:

PDF, 273 KB

english, 2014

41

Regulation system of serine protease production in Vibrio vulnificus strain NCIMB 2137, a metalloprotease-gene negative strain isolated from a diseased eel

Elgaml, Abdelaziz, Higaki, Kazutaka, Miyoshi, Shin-ichi

Journal:

Year:

2013

Language:

english

File:

PDF, 482 KB

english, 2013

42

Development of extended-release solid dispersion granules of tacrolimus: evaluation of release mechanism and human oral bioavailability

Tsunashima, Daisuke, Yamashita, Kazunari, Ogawara, Ken-ichi, Sako, Kazuhiro, Hakomori, Tadashi, Higaki, Kazutaka

Journal:

Journal of Pharmacy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 788 KB

english, 2017

43

The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption

Inoue, Daisuke, Tanaka, Akiko, Kimura, Shunsuke, Kiriyama, Akiko, Katsumi, Hidemasa, Yamamoto, Akira, Ogawara, Ken-ichi, Kimura, Toshikiro, Higaki, Kazutaka, Yutani, Reiko, Sakane, Toshiyasu, Furubaya

Journal:

European Journal of Pharmaceutical Sciences

Year:

2018

Language:

english

File:

PDF, 717 KB

english, 2018

44

Pharmacokinetic analysis of new synthetic antimalarial N-251

Okada, Kazuaki, Sato, Akira, Hiramoto, Akiko, Isogawa, Rena, Kurosaki, Yuji, Higaki, Kazutaka, Miyoshi, Shin-Ichi, Chang, Kyung-Soo, Kim, Hye-Sook

Journal:

Tropical Medicine and Health

Year:

2019

Language:

english

File:

PDF, 1006 KB

english, 2019

45

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

Akira Sato, Akiko Hiramoto, Masayuki Morita, Masahiro Matsumoto, Yuka Komich, Yukari Nakase, Natsuki Tanigawa, Osamu Hiraoka, Kazuyuki Hiramoto, Hikoya Hayatsu, Kazutaka Higaki, Satoru Kawai, Araki Ma

Journal:

Parasitology International

Year:

2011

Language:

english

File:

PDF, 443 KB

english, 2011

46

Design and Evaluation of Emulsion Generation Device Using Ultrasonic Vibration and Microchannel

Kanda, Takefumi, Harada, Takuya, Tominaga, Yoshiyuki, Suzumori, Koichi, Ono, Tsutomu, Iwabuchi, Sotaro, Ito, Kazuyuki, Ogawara, Ken-ichi, Higaki, Kazutaka, Yoshizawa, Yuta

Journal:

Japanese Journal of Applied Physics

Year:

2011

Language:

english

File:

PDF, 1.08 MB

english, 2011

47

Human proton/oligopeptide transporter (POT) genes: Identification of putative human genes using bioinformatics

Christopher W. Botka, Thomas W. Wittig, Richard C. Graul, Carsten Uhd Nielsen, Wolfgang Sadée, Kazutaka Higaki, Gordon L. Amidon

Journal:

The AAPS Journal

Year:

2000

Language:

english

File:

PDF, 735 KB

english, 2000

48

Strategies for overcoming the stratum corneum

Dr Kazutaka Higaki, Chomchan Amnuaikit…

Journal:

American Journal of Drug Delivery

Year:

2003

Language:

english

File:

PDF, 385 KB

english, 2003

49

Evaluation of pharmacokinetic/pharmacodynamic indices of topical ophthalmic gatifloxacin against Staphylococcus aureus utilising an in vitro aqueous humour pharmacokinetic model

Kozai, Seiko, Wada, Tomoyuki, Ogawara, Ken-ichi, Kida, Tetsuo, Tokushige, Hideki, Higaki, Kazutaka

Journal:

International Journal of Antimicrobial Agents

Year:

2016

Language:

english

File:

PDF, 431 KB

english, 2016

50

Preservative activity and in vivo percutaneous penetration of butylparaben entrapped in liposomes.

KOMATSU, HIDEO, HIGAKI, KAZUTAKA, OKAMOTO, HIROKAZU, MIYAGAWA, KAZUKO, HASHIDA, MITSURU, SEZAKI, HITOSHI

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 1.34 MB

1986

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